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KMID : 0984919990010010008
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Journal of Skin Barrier Research
1999 Volume.1 No. 1 p.8 ~ p.21
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Understanging the Skin Bairrer
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Lee Seung-Hun
Chung Tae-Suk
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Abstract
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The skin is a special organ which acts as a barrier to water loss and protecs the body from environmental hazards. Recently, many new concepts and studies about this field have been accoplished. The stratum corneum plays a major part in the barrier function and is composed of protein-rich cornecotyes and intercellular lipid. Epidermal lipids including ceramide, free fatty acid, and cholesterol have important role as barriers to water loss, aids to recovery from pertubation of barrier function, initiators of apoptosis and regulators of cellular proliferation, lonic change, especially change in the calcium gradient, also affects the recovery of the skin barrier function.
Herein, we summarize studies about the skin as a barrier including the following topics: basic concepts of the skin as a barrier, formation of the stratum corueum, epidermal lipids, pertubation of the skin barrier and its recovery, and the relationship between ionic changes, cytoknies, synthesis of DNA, skin aging, and the barrier function.
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KEYWORD
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Skin bairrar, stratum corneum, epidermal lipid
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